In contrast, areas of the OFC centered around the lateral orbital sulcus responded maximally to negatively perceived prospects, even when such prospects were associated with decreases in preparatory cognitive control. 
The ventrolateral component of this region extending as far as the lateral orbital sulcus has architectonic characteristics similar to those of the ventrolateral prefrontal region labelled by Walker as area 12 in the macaque monkey.
Layers III and V contain the greatest density of NFTs and these are most dense in the dysgranular areas, posterior to the transverse orbital sulcus.
TS-TPNs were distributed in an upper bank of the orbital sulcus of SI.
The spatial extent of the visually responsive region of insular cortex was assessed and was found to be limited to a surface area of approximately 6-8 mm2, the perimeter being delimited caudally by visually unresponsive cortex of the anterior sylvian gyrus, rostrally by the cortex surrounding the posterior third of the orbital sulcus (ventral bank), dorsally by the rostral extension of the dorsal bank of the anterior ectosylvian sulcus, and ventrally by a visually unresponsive zone bounded by a region about 2 mm2 ventrolateral from the anterior ectosylvian sulcal infolding.
Rostrally this projection is continuous with a projection to the entire frontal cortex located rostral and medial to the orbital sulcus.
Horseradish peroxidase (HRP) histochemistry and double labeling with the fluorescent dyes nuclear yellow (NY) and fast blue (FB) were used to examine and compare the laminar and tangential arrangement of ipsilateral (associational) and contralateral (callosal) neurons and their relative density in three regions of prefrontal granular cortex: Walker's area 46 (principal sulcus), area 8A (superior limb of the arcuate sulcus), and area 11 (lateral orbital sulcus).
Several corroborative lines of evidence indicated that tooth pulp-evoked FFPs and ENFPs originate from the following generator sources: I, inferior alveolar (dental) nerve/semilunar (gasserian) ganglion; IIa,b, trigeminal lemniscal fibers from the principal (main) sensory nucleus; IIIa,b, thalamocortical fibers from the thalamic ventral posteromedial nucleus; P1, N1, cytoarchitectural area 3 on the banks of the coronal or orbital sulcus.
Two separate areas of VPC were explored: a lateral area in the lower prefrontal convexity and a medial area around the medial orbital sulcus.
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